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complementtech C1 是級(jí)聯(lián)中的第一個(gè)補(bǔ)體成分，稱(chēng)為補(bǔ)體經(jīng)典途徑。C1 與抗原（免疫復(fù)合物）結(jié)合的抗體結(jié)合并被其激活，從而產(chǎn)生啟動(dòng)級(jí)聯(lián)反應(yīng)的蛋白酶。C1 實(shí)際上是三種不同蛋白質(zhì)（C1q、C1r 和 C1s）在鈣依賴(lài)性復(fù)合物中結(jié)合在一起的非共價(jià)復(fù)合物。C1q 通過(guò)其六個(gè)臂中的兩個(gè)或多個(gè)與 IgG 或 IgM 的 Fc 結(jié)構(gòu)域結(jié)合。多臂與免疫復(fù)合物的結(jié)合被認(rèn)為會(huì)引入壓力，導(dǎo)致復(fù)合物中的兩種 C1r 蛋白（蛋白酶原）自動(dòng)激活自身，產(chǎn)生兩種活性 C1r s氨酸蛋白酶（Morikis, D. 和 Lambris, JD (2005)） . 這些活化的 C1r 亞基切割并激活復(fù)合物中的兩個(gè) C1s 蛋白酶酶原。活化的 C1s 裂解補(bǔ)體成分 C4，釋放 C4a 并啟動(dòng) C4b 與活化表面的共價(jià)連接。活化的 C1s 也切割 C2，C2 的較大片段與表面連接的 C4b 結(jié)合，形成 C4b、C2a，它是經(jīng)典途徑的 C3/C5 轉(zhuǎn)化酶。
上海起發(fā)complementtech2022年現(xiàn)貨
| 貨號(hào) | 品名 | 規(guī)格 | 品牌 |
| B101 | GVB° (without Ca and Mg)* | 1Liter | ComplementTech |
| A113c | C3 (concentrated) 5.0 mg/ml | 1000 µg/vial | ComplementTech |
| A120 | C5 1.0 mg/ml | 250 µg/vial | ComplementTech |
| A127 | SC5b-9 Complex 1.0 mg/ml | 100µg | ComplementTech |
| A124 | C7 Protein | 250 μg/via | complementtech |
| A125 | C8 Purified Human Complement Protein | 250μg/vial | complementtech |
| A314 | C3-Dpl | 1ml/vial | complementtech |
| M099 | Mouse C1q | 100µg/vial | complementtech |
| R114 | Rat C3b *(NEW)* | 100μg | complementtech |
| B102 | GVB++ (with Ca and Mg) - 250ml | 250ml | complementtech |
| A337 | Factor H-Depleted Serum | 1.0 ml/vial | complementtech |
| A139 | Complement Factor P (Properdin) | 100μg | complementtech |
| M113 | Mouse C3 1.0 mg/ml | 1Vial | ComplementTech |
| R137 | Rat Factor H | 100µg/vial | complementtech |
| A106 | C4a 0.5 mg/ml | 50μg/vial | ComplementTech |
| A336 | Factor D-Dpl | 1ml/vial | complementtech |
| A104 | C1s Enzyme 1.0 mg/ml | 250 μg/vial | ComplementTech |
| A114 | C3b 1.0 mg/ml | 250 μg/vial | ComplementTech |
| A114 | C3b 1.0 mg/ml | 250 μg/vial | ComplementTech |
| A108 | C4b 1.0 mg/ml | 250μg/vial | ComplementTech |
| A117 | C3d | 100µg/vial | complementtech |
| A105 | C4 1.0 mg/ml | 250 μg/vial | ComplementTech |
| A100 | C1q (40% Glycerol) | 1mg | complementtech |
| A122 | C5b,6 Complex | 50 μg/vial | complementtech |
| A119 | C3a desArg | 50μg/vial | ComplementTech |
| A136 | Factor D | 25μg/vial | complementtech |
| A126 | C9 Protein | 250 μg/vial | complementtech |
| C1040 | C1s-C1INH Complex *(NEW)* | 50 μg/vial | complementtech |
| A098 | C1 0.2 mg/ml | 200 μg/vial | ComplementTech |
| A103 | C1s Proenzyme 1.0 mg/ml | 250 μg/vial | complementtech |
| A323 | C6-Dpl | 1ml | complementtech |
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